Chronopharmacological study of physical dependence on morphine in rats.
نویسندگان
چکیده
منابع مشابه
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Background: Morphine and lidocaine are known to influence the perception of pain. The present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (MND), morphine dependent (MD) and morphine withdrawal (MW) animals. Methods: Adult male Wistar rats were divided into four groups: Control, MND, MD and MW rats. Lidocai...
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This study investigated the effect of delta opioid receptor blockade by naltrindole on the development of physical dependence and tolerance to the antinociceptive and respiratory depressive effects of morphine in rats. Chronic morphine was delivered either by s.c. injection of increasing amounts of morphine over 5 days or by s.c. implantation of morphine pellets. Animals were cotreated with sal...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1985
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.85.17